منابع مشابه
GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo.
The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) signaling pathway is thought to play an important role in the induction of neutrophil mobilization from the bone marrow in response to granulocyte-colony stimulating factor (G-CSF) treatment. CXCR4 belongs to the family of G protein-coupled receptors. Multiple members of this receptor family are desensitized by agonist-i...
متن کاملExercise delays neutrophil apoptosis by a G-CSF-dependent mechanism.
The aim of the study was to determine whether exercise affects neutrophil apoptosis and to characterize the underlying mechanisms. Using annexin V labeling, neutrophil apoptosis was measured using flow cytometry after various bouts of exercise (marathon run, concentric/eccentric treadmill exercise, moderate/intensive resistance training) and in vitro conditions. Similarly, apoptosis-related mar...
متن کاملNeutrophil chemotaxis and anaesthesia.
Using a modified Boyden technique, the ability of normal human neutrophils to migrate in response to chemotactic stimulation was evaluated during exposure in vitro to halothane and thiopentone. No abnormality in neutrophil chemotaxis could be demonstrated with either agent at concentrations used clinically. The anaesthetics also did not effect serum complement, which was used as the chemotactic...
متن کاملCalpain regulates neutrophil chemotaxis.
Cell polarization is required for directed cell migration. We investigated the role of the calcium-dependent protease calpain during neutrophil chemotaxis and found that calpain inhibition induced neutrophil adhesion, polarization, and rapid chemokinesis in the absence of exogenous activators. Resting neutrophils display constitutive calpain activity with mu-calpain being the predominant active...
متن کاملAdenosine promotes neutrophil chemotaxis
We have previously (1-4) demonstrated that adenosine, by engaging specific receptors on the surface of neutrophils, inhibits generation of toxic oxygen metabolites by activated neutrophils and prevents these activated neutrophils from injuring endothelial cells. We now report the surprising observation that engagement of these same neutrophil adenosine receptors promotes chemotaxis to C5 fragme...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1995
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.1995.tb03410.x